Warfarin Online



How and where to order Warfarin Sodium (Coumadin) 1 mg, 2 mg, 5 mg tablets or capsules online on the National Blood Data Resource Center website:

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Forms:Coumadin (Warfarin Sodium) 1 mg, 2 mg, 5 mg tablets
Quantity:30-360 pills
Type:Warfarin brand, Coumadin generic
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Warfarin (trade names include Coumadin, Jantoven, Maforan, Apo-Warfarin, Marevan, Orfarin, Taro-Warfarin, Waran, Warf) is an antithrombotic agent from Vitamin K antagonists pharmacological group. This medication is used as anticoagulant for the treatment of blood clots such as first and recurrent events of pulmonary embolism, deep vein thrombosis, heart attack, heart failure, antiphospholipid syndrome, chronic central venous catheterization, ST-segment elevation myocardial infarction (STEMI), protein S deficiency, for orthopedic surgery, to prevent thrombosis, thromboembolism and stroke in people who have atrial fibrillation, valvular heart disease or artificial heart valves, for prophylaxis of deep vein thrombosis after hip replacement surgery, knee replacement surgery. It works as blood thinner by inhibiting the vitamin K-dependent synthesis of biologically active forms of the clotting factors.


Coumadin (Warfarin Sodium) tablets


Related medications:

  • Acenocoumarol (Sintrom)
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  • Amlodipine (Norvasc)
  • Aspirin, Dipyridamole (Aggrenox)
  • Cilostazol (Pletal)
  • Clopidogrel (Plavix)
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  • Rivaroxaban (Xarelto)
  • Ticagrelor (Brilinta)
  • Ticlopidine (Ticlid)
  • Tioclomarol
  • Tolvaptan (Samsca)
  • Trimetazidine (Vastarel)
  • Verapamil (Calan)


    Pharmacological and medical categories:

  • Anti thrombosis medicines
  • Anticoagulants
  • Antithrombotic drugs
  • Antiplatelet agents
  • Blood thinners
  • Cardiovascular medications


    ATC codes:

  • B - Blood and blood forming organs
  • B01 - Antithrombotic agents
  • B01A - Antithrombotic agents
  • B01AA - Vitamin K antagonists
  • B01AA03 - Warfarin


    ICD-10 codes:

  • Other coagulation defects - D68
  • Other primary thrombophilia - D68.59
  • Antiphospholipid syndrome - D68.61
  • Acute myocardial infarction - I21
  • ST elevation (STEMI) myocardial infarction of unspecified site - I21.3
  • Pulmonary embolism - I26
  • Endocarditis, valve unspecified - I38
  • Atrial fibrillation and flutter - I48
  • Heart failure - I50
  • Complications and ill-defined descriptions of heart disease - I51
  • Cerebral infarction - I63
  • Arterial embolism and thrombosis - I74
  • Embolism and thrombosis of unspecified artery - I74.9
  • Other venous embolism and thrombosis - I82
  • Acute embolism and thrombosis of unspecified vein - I82.90
  • Complications following infusion, transfusion and therapeutic injection - T80
  • Orthopedic aftercare - Z47
  • Presence of cardiac and vascular implants and grafts - Z95
  • Presence of prosthetic heart valve - Z95.2
  • Presence of other functional implants - Z96
  • Presence of right artificial hip joint - Z96.641
  • Presence of right artificial knee joint - Z96.651


    Indications and usage:

    Coumadin (Warfarin Sodium) is a vitamin K antagonist indicated for:

  • Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism.
  • Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement.
  • Reduction in the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction.

    Limitations of use

    Coumadin has no direct effect on an established thrombus, nor does it reverse ischemic tissue damage.


    Dosage and administration:

  • Individualize dosing regimen for each patient, and adjust based on INR response.
  • Knowledge of genotype can inform initial dose selection.
  • Monitoring: obtain daily INR determinations upon initiation until stable in the therapeutic range. Obtain subsequent INR determinations every 1 to 4 weeks.
  • Review conversion instructions from other anticoagulants.


    Dosage forms and strengt:

    Coumadin (Warfarin Sodium) scored tablets: 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, 10 mg.


    Overdosage:

    Signs and symptoms

    Bleeding (e.g., appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries, unexplained fall in hemoglobin) is a manifestation of excessive anticoagulation.

    Treatment

    The treatment of excessive anticoagulation is based on the level of the INR, the presence or absence of bleeding, and clinical circumstances. Reversal of Coumadin anticoagulation may be obtained by discontinuing warfarin therapy and, if necessary, by administration of oral or parenteral vitamin K1.

    The use of vitamin K1 reduces response to subsequent Coumadin (Warfarin) therapy and patients may return to a pretreatment thrombotic status following the rapid reversal of a prolonged INR. Resumption of this medication administration reverses the effect of vitamin K, and a therapeutic INR can again be obtained by careful dosage adjustment. If rapid re-anticoagulation is indicated, heparin may be preferable for initial therapy.

    Prothrombin complex concentrate (PCC), fresh frozen plasma, or activated Factor VII treatment may be considered if the requirement to reverse the effects of Coumadin is urgent. A risk of hepatitis and other viral diseases is associated with the use of blood products; PCC and activated Factor VII are also associated with an increased risk of thrombosis. Therefore, these preparations should be used only in exceptional or life-threatening bleeding episodes secondary to Warfarin Sodium overdosage.


    Contraindications:

  • Pregnancy, except in women with mechanical heart valves.
  • Hemorrhagic tendencies or blood dyscrasias.
  • Recent or contemplated surgery of the central nervous system (CNS) or eye, or traumatic surgery resulting in large open surfaces.
  • Bleeding tendencies associated with certain conditions.
  • Threatened abortion, eclampsia, and preeclampsia.
  • Unsupervised patients with potential high levels of non-compliance.
  • Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding.
  • Hypersensitivity to warfarin or any component of the product.
  • Major regional or lumbar block anesthesia.
  • Malignant hypertension.


    Warnings and precautions:

  • Tissue necrosis: necrosis or gangrene of skin or other tissues can occur, with severe cases requiring debridement or amputation. Discontinue Coumadin (Warfarin Sodium) and consider alternative anticoagulants if necessary.
  • Calciphylaxis: fatal and serious cases have occurred. Discontinue Coumadin and consider alternative anticoagulation therapy.
  • Acute kidney injury may occur during episodes of excessive anticoagulation and hematuria.
  • Systemic atheroemboli and cholesterol microemboli: some cases have progressed to necrosis or death. Discontinue warfarin if such emboli occur.
  • Heparin-induced thrombocytopenia (HIT): initial therapy with Coumadin in HIT has resulted in cases of amputation and death. Warfarin may be considered after platelet count has normalized.
  • Pregnant women with mechanical heart valves: Warfarin Sodium (Coumadin) may cause fetal harm; however, the benefits may outweigh the risks.


    Adverse reactions, side effects:

    Most common adverse reactions to warfarin are fatal and nonfatal hemorrhage from any tissue or organ.

    To report suspected adverse reactions of Coumadin (Warfarin Sodium) tablets, contact Bristol-Myers Squibb pharmaceutical company or your local FDA.


    Drug interactions:

  • Concomitant use of drugs that increase bleeding risk, antibiotics, antifungals, botanical (herbal) products, and inhibitors and inducers of CYP2C9, 1A2, or 3A4.
  • Consult labeling of all concurrently used drugs for complete information about interactions with Coumadin or increased risks for bleeding.


    Use in specific populations:

  • Pregnant women with mechanical heart valves: Coumadin (Warfarin) may cause fetal harm; however, the benefits may outweigh the risks.
  • Lactation: monitor breastfeeding infants for bruising or bleeding.
  • Renal impairment: instruct patients with renal impairment to frequently monitor their INR.


    Pregnancy categories:

  • D - Australia
  • X - United States (Should not be used during pregnancy)


    Salts and other forms:

  • Warfarin Base
  • Warfarin Potassium
  • Warfarin Sodium
  • Warfarin Sodium Clathrate


    Synonyms, international and chemical names:

  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-
  • Antrombin K
  • Coumaphene
  • Varfariin
  • Varfariini
  • Varfarin
  • Varfarina
  • Warfairin
  • Warfarina
  • Warfarine
  • Warfarinum
  • Warfaryna
  • Warffarin


    Brands, generics, trade names:

  • Aldocumar - Aldo Union
  • Apo-Warfarin - Apotex, Hind Wing, Pharmaforte
  • Coumadin - Bristol-Myers Squibb
  • Jantoven - USL Pharmaceuticals
  • Maforan - Sriprasit
  • Marevan - GlaxoSmithKline
  • Orfarin - Orion Pharma
  • Panwarfin - Abbott
  • Sofarin - Teva, Samarth Pharma
  • Taro-Warfarin - Taro Pharmaceutical Industries
  • Waran - Nycomed
  • Warf - Cipla
  • Warfarin - Sandoz, Teva, Watson Pharmaceuticals


    Here is a list of popular medications containing warfarin as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Coumadin
  • Injectable; Injection; Warfarin Sodium 5 mg
  • Injectable; Injection; Warfarin Sodium 50 mg
  • Injectable; Injection; Warfarin Sodium 75 mg
  • Tablets; Oral; Warfarin Sodium 1 mg
  • Tablets; Oral; Warfarin Sodium 2 mg
  • Tablets; Oral; Warfarin Sodium 2.5 mg
  • Tablets; Oral; Warfarin Sodium 3 mg
  • Tablets; Oral; Warfarin Sodium 4 mg
  • Tablets; Oral; Warfarin Sodium 5 mg
  • Tablets; Oral; Warfarin Sodium 6 mg
  • Tablets; Oral; Warfarin Sodium 7.5 mg
  • Tablets; Oral; Warfarin Sodium 10 mg
  • Bristol-Myers Squibb
  • B. Braun
  • Boots
  • Healthcare Logistics
  • Invida
  • Sanofi
  • Sigma Pharmaceuticals
  • Taro Pharmaceutical Industries
  • Zentiva
  • Zuellig Pharma
  • Zuoz Pharma
  • Marevan
  • Tablets; Oral; Warfarin Sodium 1 mg
  • Tablets; Oral; Warfarin Sodium 3 mg
  • Tablets; Oral; Warfarin Sodium 5 mg
  • GlaxoSmithKline
  • Boots
  • Farmoquimica
  • Goldshield Pharmaceuticals
  • Institute of Pharmaceutical Research and Technology
  • Nycomed
  • Orion Pharma
  • Sigma Pharmaceuticals
  • Therabel Pharma
  • Zuellig Pharma
  • Orfarin
  • Tablets; Oral; Warfarin Sodium 3 mg
  • Tablets; Oral; Warfarin Sodium 5 mg
  • Orion Pharma
  • Apex Pharmacy
  • Harn Thai Pharma
  • Pharmacon
  • Rigel Pharma



  • References:

  • Warfarin main article on Wikipedia: https://en.wikipedia.org/wiki/Warfarin
  • Warfarin compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Warfarin
  • Warfarin Sodium compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Warfarin-sodium
  • Warfarin on DrugBank: https://go.drugbank.com/drugs/DB00682
  • Warfarin Sodium on DrugBank: https://go.drugbank.com/salts/DBSALT000278
  • Warfarin FAQ on MedlinePlus (revised 06/15/2017): https://medlineplus.gov/druginfo/meds/a682277.html
  • Taking Warfarin (Coumadin) FAQ on MedlinePlus (revised 01/28/2019): https://medlineplus.gov/ency/patientinstructions/000292.htm
  • Blood thinners (anti-platelet drugs, anticoagulants) review on MedlinePlus: https://medlineplus.gov/bloodthinners.html
  • Warfarin Sodium tablets drug label info on DailyMed (revised December 29, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Coumadin (Warfarin Sodium) tablets drug label info on DailyMed (revised August 14, 2012): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Warfarin containing drugs on Drugs-About.com: https://drugs-about.com/ing/warfarin.html
  • Warfarin for sale on Pharma Doctor: https://pharma-doctor.com/warfarin.html
  • Warfarin international drug names on Drugs.com: https://www.drugs.com/international/warfarin.html
  • Coumadin (Warfarin Sodium) tablets for oral use and injections for intravenous use official prescribing information and medication guide from the U.S. FDA (revised 10/2011): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Coumadin (Warfarin Sodium) tablets for oral use prescribing information and medication guide from Bristol-Myers Squibb pharmaceutical company (revised 12/2019): https://packageinserts.bms.com/pi/pi_coumadin.pdf
  • Marevan (Warfarin Sodium) tablets prescribing information from the Therapeutic Goods Administration (revised 16/03/2020): https://www.ebs.tga.gov.au/ebs/picmi/...
  • Marevan (Warfarin Sodium) tablets consumer medicine information from the Therapeutic Goods Administration (revised March 2020): https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/...
  • Orfarin (Warfarin Sodium) tablets prescribing information from MIMS: https://www.mims.com/thailand/drug/info/orfarin?type=full
  • Sun Pharma Warfarin Sodium 0.5 mg, 1 mg, 3 mg, 5 mg tablets patient information leaflet on Medicines.org.uk (revised 07/2020): https://www.medicines.org.uk/emc/files/pil.3064.pdf

    Revised: June 2021



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