Buy Warfarin (Coumadin) online
How and where to order Warfarin Sodium (Coumadin) 1 mg, 2 mg, 5 mg tablets or capsules online:
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Indications and usage:
Coumadin (Warfarin Sodium) is a vitamin K antagonist indicated for:
Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism.
Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement.
Reduction in the risk of death, recurrent myocardial infarction, and thromboembolic events such as stroke or systemic embolization after myocardial infarction.
Limitations of use
Coumadin has no direct effect on an established thrombus, nor does it reverse ischemic tissue damage.
Dosage and administration:
Individualize dosing regimen for each patient, and adjust based on INR response.
Knowledge of genotype can inform initial dose selection.
Monitoring: obtain daily INR determinations upon initiation until stable in the therapeutic range. Obtain subsequent INR determinations every 1 to 4 weeks.
Review conversion instructions from other anticoagulants.
Dosage forms and strengt:
Coumadin (Warfarin Sodium) scored tablets 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, 10 mg.
Coumadin (Warfarin Sodium) 5 mg lyophilized powder for injection in single-dose vial.
Contraindications:
Pregnancy, except in women with mechanical heart valves.
Hemorrhagic tendencies or blood dyscrasias.
Recent or contemplated surgery of the central nervous system (CNS) or eye, or traumatic surgery resulting in large open surfaces.
Bleeding tendencies associated with certain conditions.
Threatened abortion, eclampsia, and preeclampsia.
Unsupervised patients with potential high levels of non-compliance.
Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding.
Hypersensitivity to warfarin or any component of the product.
Major regional or lumbar block anesthesia.
Malignant hypertension.
Warnings and precautions:
Tissue necrosis: necrosis or gangrene of skin or other tissues can occur, with severe cases requiring debridement or amputation. Discontinue Coumadin (Warfarin Sodium) and consider alternative anticoagulants if necessary.
Calciphylaxis: fatal and serious cases have occurred. Discontinue Coumadin and consider alternative anticoagulation therapy.
Acute kidney injury may occur during episodes of excessive anticoagulation and hematuria.
Systemic atheroemboli and cholesterol microemboli: some cases have progressed to necrosis or death. Discontinue warfarin if such emboli occur.
Heparin-induced thrombocytopenia (HIT): initial therapy with Coumadin in HIT has resulted in cases of amputation and death. Warfarin may be considered after platelet count has normalized.
Pregnant women with mechanical heart valves: Warfarin Sodium (Coumadin) may cause fetal harm; however, the benefits may outweigh the risks.
Overdosage:
Signs and symptoms
Bleeding (e.g., appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries, unexplained fall in hemoglobin) is a manifestation of excessive anticoagulation.
Treatment
The treatment of excessive anticoagulation is based on the level of the INR, the presence or absence of bleeding, and clinical circumstances. Reversal of Coumadin anticoagulation may be obtained by discontinuing warfarin therapy and, if necessary, by administration of oral or parenteral vitamin K1.
The use of vitamin K1 reduces response to subsequent Coumadin (Warfarin) therapy and patients may return to a pretreatment thrombotic status following the rapid reversal of a prolonged INR. Resumption of this medication administration reverses the effect of vitamin K, and a therapeutic INR can again be obtained by careful dosage adjustment. If rapid re-anticoagulation is indicated, heparin may be preferable for initial therapy.
Prothrombin complex concentrate (PCC), fresh frozen plasma, or activated Factor VII treatment may be considered if the requirement to reverse the effects of Coumadin is urgent. A risk of hepatitis and other viral diseases is associated with the use of blood products; PCC and activated Factor VII are also associated with an increased risk of thrombosis. Therefore, these preparations should be used only in exceptional or life-threatening bleeding episodes secondary to Warfarin Sodium overdosage.
Adverse reactions, side effects:
Most common adverse reactions to warfarin are fatal and nonfatal hemorrhage from any tissue or organ.
To report suspected adverse reactions of Coumadin (Warfarin Sodium) tablets, contact Bristol-Myers Squibb pharmaceutical company or your local FDA.
Drug interactions:
Concomitant use of drugs that increase bleeding risk, antibiotics, antifungals, botanical (herbal) products, and inhibitors and inducers of CYP2C9, 1A2, or 3A4.
Consult labeling of all concurrently used drugs for complete information about interactions with Coumadin or increased risks for bleeding.
Use in specific populations:
Pregnant women with mechanical heart valves: Coumadin (Warfarin) may cause fetal harm; however, the benefits may outweigh the risks.
Lactation: monitor breastfeeding infants for bruising or bleeding.
Pediatric use: pediatric use is based on adult data and recommendations, and available limited pediatric data from observational studies and patient registries.
Geriatric use: no overall differences in effectiveness or safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
Renal impairment: instruct patients with renal impairment to frequently monitor their INR.
Hepatic impairment: hepatic impairment can potentiate the response to warfarin through impaired synthesis of clotting factors and decreased metabolism of warfarin. Use caution when using this medication in these patients.
Where to buy warfarin online:
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Here is a list of popular medications containing warfarin sodium as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
Trade name of the drug |
Pharmaceutical forms and doses |
Companies |
Coumadin |
Injectable; Injection; 5 mg, 50 mg, 75 mgTablets; Oral; 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, 10 mg |
Bristol-Myers SquibbB. BraunBootsInvidaSanofiSigma PharmaceuticalsTaro Pharmaceutical IndustriesZentiva |
Marevan |
Tablets; Oral; 1 mg, 3 mg, 5 mg |
GlaxoSmithKlineBootsNycomedOrion PharmaSigma Pharmaceuticals |
Orfarin |
Tablets; Oral; 3 mg, 5 mg |
Orion Pharma |
Warf |
Tablets; Oral; 1 mg, 2 mg, 3 mg, 4 mg, 5 mg, 10 mg |
Cipla |
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